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Haematolymphoid Tumors
Divided into Lymphomas and Histiocytic Neoplasms involving the CNS.
Subtypes2
Grade Range
G1G4
Subtypes
Primary CNS diffuse large B-cell lymphoma (PCNSL)
WHO Grade 4
Malignant haematolymphoid (>90% of CNS lymphomas). Classically periventricular.
Diagnostic Molecular Markers
MYD88 L265P mutation (>70%)CD79B mutation
Locations:
Langerhans cell histiocytosis (LCH)
WHO Grade 1
Clonal histiocytic disorder affecting the hypothalamic-pituitary axis.
Diagnostic Molecular Markers
BRAF V600E (>50%)
Locations:
Primary Locations
Clinical Note
Grading and diagnostic criteria listed here are based strictly on the 2021 WHO Classification of Tumours of the Central Nervous System (5th Edition). Many entities now require integrated phenotypic and genotypic characterization for a final diagnosis.