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Metastases to the CNS
Secondary neoplasms reaching the CNS hematogenously or via direct contiguity.
Subtypes2
Grade Range
G4
Subtypes
Intraparenchymal Brain Metastases
WHO Grade 4
Most common from lung, breast, melanoma, RCC. Typically found at gray-white matter junctions.
Leptomeningeal Carcinomatosis
WHO Grade 4
Tumor seeding in the subarachnoid space and basilar cisterns.
Locations:
Clinical Note
Grading and diagnostic criteria listed here are based strictly on the 2021 WHO Classification of Tumours of the Central Nervous System (5th Edition). Many entities now require integrated phenotypic and genotypic characterization for a final diagnosis.