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Tumors of the Sellar Region
Tumors arising in the pituitary fossa, neurohypophysis, infundibulum, and Rathke's pouch.
Subtypes3
Grade Range
G1G2
Subtypes
Pituitary neuroendocrine tumor (PitNET)
WHO Grade 1WHO Grade 2
Also known as pituitary adenoma. Classified by transcription factors (PIT1, TPIT, SF1).
Diagnostic Molecular Markers
GNAS, PRKAR1A, AIP
Locations:
Adamantinomatous craniopharyngioma
WHO Grade 1
Classically pediatric. Machinery oil cyst fluid.
Diagnostic Molecular Markers
CTNNB1 (beta-catenin) mutation
Locations:
Papillary craniopharyngioma
WHO Grade 1
Almost exclusively found in adults.
Diagnostic Molecular Markers
BRAF V600E mutation (>95%)
Locations:
Primary Locations
Clinical Note
Grading and diagnostic criteria listed here are based strictly on the 2021 WHO Classification of Tumours of the Central Nervous System (5th Edition). Many entities now require integrated phenotypic and genotypic characterization for a final diagnosis.